Smart cards have been around since 1974 and as a technology while they have expanded their capabilities they still work in very much the same way they did back then.

These cards expose a protocol represented in Application Data Units (APDUs), the devices themselves are typically connected to computers via smart card readers (either embedded or external) that communicate via PC/SC.

Shortly after PC/SC was defined a class interface for USB PC/SC devices was defined called CCID with devices that conform to this specification one does not need vendor specific drivers to interact with the PC/SC device.

Since Chrome 26 Google has supported an interface that allows plug-ins to interact with USB devices. While I have not looked at this interface in detail I do know that the Google Gnubby (aka FIDO U2F) uses this interface to interact with their devices. I also understand that the U2F devices are in simple JCOP cards with a Gnubby applet on them.

Based on the above it seems rational to believe a third-party (aka someone other than Google) should also be able to create a Chrome plug-in (which is nothing more than Javascript) that allows a web-page to interact with smart-cards.

This would when paired with a reasonable card-edge that supports secp256k1 enable Multi-signature Bitcoin transactions leveraging smart cards without the need for a “fat” client.